Explore our solutions for cryo-EM data analysis and 3D reconstruction.
Trusted by researchers worldwide, CryoSPARC™ is a powerful, end-to-end platform for single-particle cryo-EM, combining cutting-edge 3D reconstruction algorithms with an intuitive, streamlined workflow. From motion correction to atomic resolution, CryoSPARC enables rapid and reliable structure determination of biologically important targets — including challenging samples such as membrane proteins, GPCRs, ion channels, and flexible or heterogeneous complexes.
From microscope to structure, in minutes. CryoSPARC Live™ delivers real-time cryo-EM data processing, quality assessment, and feedback as data is collected — enabling immediate decision-making and optimization. Whether during acquisition or post-session, CryoSPARC Live™ provides the fastest, most streamlined path to high-resolution structures.
In collaboration with Thermo Fisher Scientific, we’ve developed Embedded CryoSPARC Live — a version of CryoSPARC Live™ designed for seamless integration with Thermo Scientific™ cryo-TEM systems. Embedded directly onto microscope hardware, it works in tandem with Thermo Scientific™ CryoFlow™ and Smart EPU software, bringing real-time data analysis directly into your cryo-EM environment.