We are unlocking the potential of cryo-electron microscopy
(cryo-EM) as a high-throughput structure determination technique for life sciences and drug discovery.
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coronavirus spike protein structure alt
coronavirus spike protein structure alt hidden-image
coronavirus spike protein structure alt hidden-image


Cryo-EM is a recent Nobel Prize-winning technique for microscopy and 3D reconstruction of proteins and other biological molecules. A sample containing proteins and protein-ligand complexes is frozen in a thin film of ice and subsequently imaged in an electron microscope. The resulting microscopy data is analyzed via complex algorithms to identify the contents of the sample and solve the 3D atomic structures of the embedded protein molecules in their near-native states.


Structura Bio's state-of-the-art cryoSPARC platform is used globally for cryo-EM data analysis and 3D reconstruction. CryoSPARC offers specially designed, proprietary algorithms for membrane proteins, ion channels, GPCRs and drug targets with ligands bound.


Novel technologies and algorithms applied to the cryo-EM field
Building Proteins in a Day

Scientific paper describing efficient 3D molecular structure estimation accelerated with GPUs.

Founded Structura Bio

Structura Biotechnology founded to develop high-performance software solutions and advanced algorithms for cryo-EM data processing.

cryoSPARC v0 released

Ab-initio reconstruction and rapid, high-resolution refinement released in cryoSPARC along with a publication in Nature Methods.

cryoSPARC v2

Released cryoSPARC v2, a full-pipeline software solution for single-particle cryo-EM reconstruction.

cryoSPARC Live

CryoSPARC Live (BETA) was released to dozens of facilities globally for expedited preprocessing and real-time 2D and 3D processing in time with data collection.

cryoSPARC v3

Many more improvements and additions to the cryo-EM data processing workflow, advanced refinement methods, methods for modelling continuous heterogeneity and redesigned cryoSPARC Live application. CryoSPARC used to solve the first SARS-CoV-2 spike protein structure.


Institutions using cryoSPARC






Jobs run in cryoSPARC
November 30, 2020

Non-uniform Refinement: Adaptive Regularization Improves Single-particle
Cryo-EM Reconstruction

We introduce non-uniform refinement, an algorithm based on cross-validation optimization, which automatically regularizes 3D density maps during refinement to account for spatial variability.
Read the paper
November 19, 2020

Startup Uses Microscopy Breakthrough to Speed Creation of COVID-19 Vaccines

Structura Biotechnology’s groundbreaking software quickly analyzes cryo-EM data.
Read the story
February 25, 2020

Toronto Biotech Startup Plays Role in Critical Breakthrough in Coronavirus Research

Structura Biotechnology has developed a tool that is playing a key role in a “critical breakthrough” in the search for a vaccine for coronavirus, according to U of T News.
Read the story


We are looking for talented individuals to join our growing team. Send us an email at to let us know what you can bring to the team.

Open Positions


For general inquiries, please email