Scientific paper describing efficient 3D molecular structure estimation accelerated with GPUs.
Structura Biotechnology founded to develop high-performance software solutions and advanced algorithms for cryo-EM data processing.
Ab-initio reconstruction and rapid, high-resolution refinement released in CryoSPARC along with a publication in Nature Methods.
Released CryoSPARC v2, a full-pipeline software solution for single-particle cryo-EM reconstruction.
CryoSPARC Live (BETA) was released to dozens of facilities globally for expedited preprocessing and real-time 2D and 3D processing in time with data collection.
Many more improvements and additions to the cryo-EM data processing workflow, advanced refinement methods, methods for modelling continuous heterogeneity and redesigned CryoSPARC Live application. CryoSPARC used to solve the first SARS-CoV-2 spike protein structure.
Released 3D Variability Analysis, a critical tool for exploring conformational heterogeneity of proteins.
Released a redesigned and reengineered interface for processing cryo-EM data with streamlined tools for advanced workflows. Announced a major partnership with Thermo Fisher Scientific to integrate Structura’s software with microscope hardware. Released 3D Flexible Refinement, a motion-based deep generative model for continuous heterogeneity.