STRUCTURA BIOTECHNOLOGY

We are unlocking the potential of cryo-electron microscopy
(cryo-EM) as a high-throughput structure determination technique for life sciences and drug discovery.
Learn More
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coronavirus spike protein structure alt hidden-image
coronavirus spike protein structure alt hidden-image

About

Cryo-EM is a Nobel Prize-winning technique for microscopy and 3D reconstruction of proteins and other biological molecules. A sample containing proteins and protein-ligand complexes is frozen in a thin film of ice and subsequently imaged in an electron microscope. The resulting microscopy data is analyzed via complex algorithms to identify the contents of the sample and solve the 3D atomic structures of the embedded protein molecules in their near-native states.

CryoSPARC™

Structura Biotechnology's state-of-the-art CryoSPARC platform is used globally for cryo-EM data analysis and 3D reconstruction. CryoSPARC offers specially designed, proprietary algorithms for membrane proteins, ion channels, GPCRs and drug targets with ligands bound.
Learn more about cryo-EM and CryoSPARC
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Milestones

Novel technologies and algorithms applied to the cryo-EM field
2015
Building Proteins in a Day

Scientific paper describing efficient 3D molecular structure estimation accelerated with GPUs.

2016
Founded Structura Biotechnology

Structura Biotechnology founded to develop high-performance software solutions and advanced algorithms for cryo-EM data processing.

2017
CryoSPARC v0 released

Ab-initio reconstruction and rapid, high-resolution refinement released in CryoSPARC along with a publication in Nature Methods.

2018
CryoSPARC v2

Released CryoSPARC v2, a full-pipeline software solution for single-particle cryo-EM reconstruction.

2019
CryoSPARC Live

CryoSPARC Live (BETA) was released to dozens of facilities globally for expedited preprocessing and real-time 2D and 3D processing in time with data collection.

2020
CryoSPARC v3

Many more improvements and additions to the cryo-EM data processing workflow, advanced refinement methods, methods for modelling continuous heterogeneity and redesigned CryoSPARC Live application. CryoSPARC used to solve the first SARS-CoV-2 spike protein structure.

2021
3D Variability Analysis

Released 3D Variability Analysis, a critical tool for exploring conformational heterogeneity of proteins.

2022
CryoSPARC v4 + Partnership with Thermo Fisher Scientific + 3D Flexible Refinement

Released a redesigned and reengineered interface for processing cryo-EM data with streamlined tools for advanced workflows. Announced a major partnership with Thermo Fisher Scientific to integrate Structura’s software with microscope hardware. Released 3D Flexible Refinement, a motion-based deep generative model for continuous heterogeneity.

Embeded CryoSPARC Live Thermo Fisher collaboration
August 03, 2022

Thermo Fisher Scientific and Structura Biotechnology Collaborate to Offer a Solution for Real-Time Cryo-EM Data Analysis

Structura Biotechnology’s real-time processing software is to be integrated and delivered with Thermo Fisher Scientific cryo-EM microscopes.
Read the press release
November 30, 2020

Non-uniform Refinement: Adaptive Regularization Improves Single-particle
Cryo-EM Reconstruction

We introduce non-uniform refinement, an algorithm based on cross-validation optimization, which automatically regularizes 3D density maps during refinement to account for spatial variability.
Read the paper
Nature Methods
Covid-19 Spike Protein
November 19, 2020

Startup Uses Microscopy Breakthrough to Speed Creation of COVID-19 Vaccines

Structura Biotechnology’s groundbreaking software quickly analyzes cryo-EM data.
Read the story
February 25, 2020

Toronto Biotech Startup Plays Role in Critical Breakthrough in Coronavirus Research

Structura Biotechnology has developed a tool that is playing a key role in a “critical breakthrough” in the search for a vaccine for coronavirus, according to U of T News.
Read the story
Covid-19 Spike Protein Structure

Our Team

Ali Punjani
Ali Punjani
CO-FOUNDER & CEO
Saara Virani
Saara Virani
CHIEF OPERATING OFFICER
Suhail Dawood
Suhail Dawood
CHIEF PRODUCT OFFICER
Nick Frasser
Nick Frasser
SENIOR SOFTWARE ENGINEER
Harris Snyder
Harris Snyder
SCIENTIFIC COMPUTING ENGINEER
Kelly Barber
Kelly Barber
FULL-STACK DEVELOPER
Valentin Peretroukhin
Valentin Peretroukhin, PhD
COMPUTATIONAL RESEARCH SCIENTIST
Wolfram Tempel
Wolfram Tempel
Customer Success Engineer
Michael McLean
Michael McLean
COMPUTATIONAL RESEARCH ENGINEER
Nicholas Wong
Nicholas Wong
Software Engineer
Hannah Bridges, PhD
Hannah Bridges, PhD
Cryo-EM Application Scientist, Data Processing
Rich Posert, PhD
Rich Posert, PhD
Cryo-EM Application Scientist, Education and Training
Kye Stachowski, PhD
Kye Stachowski, PhD
Cryo-EM Application Scientist, Computational Workflows
Fiona Hu
Fiona Hu
Software Engineer
Serena Liu
Serena Liu
COMPUTATIONAL RESEARCH ENGINEER INTERN
Katherine Elder
Katherine Elder
COMPUTATIONAL RESEARCH ENGINEER INTERN
Marcus Brubaker, PhD
CO-FOUNDER & SCIENTIFIC ADVISOR, ML AND COMPUTER VISION
John Rubinstein, PhD
SCIENTIFIC ADVISOR, CRYO-EM
David Fleet, PhD
SCIENTIFIC ADVISOR, ML AND COMPUTER VISION

Careers

We are looking for talented individuals to join our growing team. Send us an email at careers@structura.bio to let us know what you can bring to the team.

Full Stack Developer

Contact

For general inquiries, please email info@structura.bio.